In 1609 a Mohawk war party is utterly routed. The reason? Guns. Samuel de Champlain the Father of New France accompanied his new Huron allies on a raid into the land of the Iroquois. Indian warfare was about to drastically change. In all Champlain was a part of three battles involving the Iroquois. Two with the Mohawk and the third was a show down outside the capital city of the Onondaga.

Sources:

CHAMPLAIN'S DREAM BY DAVID HACKETT FISCHER

THE JESUITS IN NORTH AMERICA IN THE SEVENTEENTH CENTURY BY FRANCIS PARKMEN

Voyages de la Nouvelle France by Samuel de Champlain