🫀 New Nature study, old cholesterol mystery: why does LDL clearance falter under chronic dietary cholesterol stress?

Feng et al. identify a RAS–Ral–RalBP1/REPS1–CTSA pathway that diverts LDL receptor (LDLR) away from recycling and toward lysosomal degradation—independent of PCSK9. CTSA inhibition preserved LDLR and improved LDL/VLDL clearance in preclinical models.

Translation? Not clinic-ready yet, but potentially a fresh LDLR-sparing axis beyond statins, ezetimibe, and PCSK9 therapy. 🎯

#Cardiology #Lipidology #LDL #LDLR #Atherosclerosis #PrecisionMedicine #MedicalPodcasts