Can the aging brain still make new neurons?

A landmark 2026 Nature study analyzed 355,997 human hippocampal nuclei using single-nucleus RNA sequencing and ATAC sequencing. Neurogenesis persists into adulthood—but chromatin accessibility collapses early in Alzheimer's disease.

SuperAgers showed a 2.5-fold increase in immature neurons and a preserved resilience signature.

Epigenetics may be the earliest battlefield in cognitive decline. 🧠