Credits: 0.25 AMA PRA Category 1 Credit™

CME/CE Information and Claim Credit: https://www.pri-med.com/online-education/podcast/frankly-speaking-cme-476

Overview: Melatonin is widely used and often perceived as a safe, natural solution for insomnia. However, a new preliminary study raises concerns about long-term melatonin use and increased risk of heart failure, hospitalization, and all-cause mortality in patients with chronic insomnia. In this episode, we review the findings, discuss how they fit with existing evidence, explore limitations, and offer practical guidance for clinicians counseling patients about sleep supplements.

Episode resource links:

• American Heart Association Scientific Sessions 2025 – Abstract 4371606
  AHA Scientific Statement: Multidimensional Sleep Health and Cardiometabolic Risk (Circulation, 2025)
• Li et al. Lancet Diabetes & Endocrinology, 2024
• American Academy of Sleep Medicine Clinical Practice Guidelines
• AHA Life’s Essential 8 & Sleep Health Resources

Guest: Mariyan Montaque, DNP, FNP-BC

Music Credit: Matthew Bugos

Thoughts? Suggestions? Email us at FranklySpeaking@pri-med.com

The views expressed in this podcast are those of Dr. Domino and his guests and do not necessarily reflect the views of Pri-Med.