This EASL Studio discusses important issues related to the opportunities and challenges of liver transplantation in acute-on-chronic liver failure (ACLF).

• Does urgent liver transplantation improve the survival of patients with ACLF-3 and where are the limits?
• Are the current allocation systems adequate and how to implement ACLF criteria for prioritisation?
• The distinct lack of equity of access of ACLF-3 patients to liver transplantation: Where are the barriers?
• What data will the CHANCE study deliver to address some of the unanswered questions?

All EASL Studio Podcasts are available on EASL Campus.