There is no denying health is complex and interconnected, which is why our response to antimicrobial resistance (AMR) should be too. A ‘One Health’ approach is about spanning lifeforms, disciplines and practice to coordinate efforts and solve AMR at a macro-level. As Professor Karin Thursky and Associate Professor Simon Reid explain, this remains a challenge around the world. Panel guests: Professor Karin Thursky and Associate Professor Simon Reid Hosted by Anthony Frangi. Recorded live at the 2019 National Antimicrobial Resistance Forum.