Dr. J R Harding, www.jrharding.com, a recognized disability leader with personal and professional experience, is a quadriplegic, author of, ‘Now What?’, accessibility expert, and international speaker who’s contributed to national, state, and community policy. Dr. Eileen Wolkstein holds the PhD in Rehabilitation Counseling from New York University. For thirty years she was a research scientist and adjunct professor in the Rehabilitation Counseling Department. They highlight their personal experiences and work. They discuss the challenges created by serious and persistent disabilities in which the co-existing disabilities are addictions at the stage of serious disabilities, and describe help for individuals living with the challenges. They say what more they would like to do and see done to promote help for individuals with the challenges created by serious and persistent disabilities in which the co-existing disabilities are addictions, and share their messages for family caregivers.