Sam Sternberg discusses his work on exploring and exploiting CRISPR-Cas immune systems, beginning as a graduate student with Jennifer Doudna, at a biotech start-up, and in his laboratory at Columbia University.

Host: Vincent Racaniello

Guest: Sam Sternberg

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Links for this episode * Sternberg Laboratory at Columbia * Mechanism of substrate selection by Cas9 (RNA) * DNA interrogation by Cas9 (Nature) * Conformational control of DNA target cleavage by Cas9 (Nature) * A Crack in Creation by Doudna and Sternberg * What if we could rewrite the human genome? (YouTube) * Sam Sternberg

Music used on TWiM is composed and performed by Ronald Jenkees and used with permission.

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