CPP is defined as MAP-ICP (or MAP-CVP, if CVP>ICP). Cerebral perfusion pressure is the major determinant of cerebral blood flow (CBF). At low and high levels of CPP, CBF is linearly related to CPP- illustrated by the well-known plot of CBF vs. CPP published by Lassen in 1959 (see figure). Along the plateau, cerebral autoregulation […]