Definition Generally speaking, renal replacement therapy is necessary to prevent either fluid overload or endogenous poisoning. Indications for starting renal replacement therapy: Oliguria (urine output <200mL/12h) Anuria/extreme oliguria (urine output <50mL/12h) Hyperkalemia ([K]>6.5mEq/L) Severe acidemia (pH<7.1) Azotemia ([urea]>30mg/dL) Clinically significant organ (especially pulmonary) edema Uremic encephalopathy, pericarditis, or neuropathy/myopathy Severe hypo- or hypernatremia ([Na]<115 or […]