Definition Structural changes: Loss of neural tissue Thickened leptomeninges in spinal cord Decreased number of serotonin, acetylcholine, and dopamine receptors Functional changes: Reduction in cerebral blood flow (decreases about 10-20%, in proportion to neuronal loss) Decline in memory, reasoning, perception  Disturbed sleep/wake cycle  Increased threshold for many sensory modalities including touch, temperature, sensation, proprioception, hearing, […]