Definition Overview Anaphylaxis is a severe, life threatening hypersensitivity reaction with rapid onset that is primarily mediated by IgE. It occurs in 1 in 10,000 to 20,000 anesthetic procedures, though the exact incidence is likely underestimated due to underreporting. The most common causative agents are neuromuscular blocking agents (NMBAs), followed by latex and antibiotics. Other […]