Definition Opioid Antagonists Naloxone (Narcan) Pure antagonist of μ, κ, and δ receptors. Must be administered with caution – if too aggressive, can elicit extreme pain, HTN, arrhythmias, pulmonary edema, and death (thought to be due to massive catecholamine response to pain), as well as opioid withdrawal symptoms in patients who require opioids. Peak effect […]