Definition Norepinephrine (NE) is an endogenous catecholamine and a direct acting adrenergic agonist. It is synthesized from dopamine by dopamine-beta-hydroxylase. NE is the body’s primary adrenergic neurotransmitter. It’s effects are mediated primarily through interaction at α-1 and β-1 receptors. It also has α-2 activity, though this primarily serves as a negative feedback system. NE is […]