Definition General: Mannitol is an Osmotic diuretic 6 carbon sugar Dose: 0.25-1.0 g/kg Filtered at the glomerulus, but does not get significant reabsorption in the proximal tubule. This osmotically prevents passive water reabsorption that would occur with the active Na+ reabsorption in the proximal tubule Rapidly acting, therefore this acutely raises plasma/extracellular osmolarity Leads to […]