Definition All inhalational agents, including isoflurane, decrease cerebral metabolic rate of oxygen (CMRO2). It is known that isoflurane can cause burst-suppression as well. The CMRO2-decreasing effect does not seem to be significantly different between isoflurane, sevoflurane, and desflurane. All intravenous induction agents, except ketamine, decrease CMRO2 but preserve CMRO2 – cerebral blood flow (CBF) coupling […]