Definition The process by which intracranial tumors produce cerebral compression was initially described over one hundred years ago. (Source 1) In the normal adult, intracranial contents (i.e. cellular mass, blood, and CSF) have a combined volume of 1200-1500 cm^3. (Source 2). The presence of a tumor (or other mass lesion, e.g. hematoma) increases intracranial volume. […]