Definition I. What is DI? A. Central DI – decreased secretion of antidiuretic hormone (ADH, aka AVP) – results in polyuria and polydipsia by diminishing the patient’s ability to concentrate urine – defect in one or more sites involving the hypothalamic osmoreceptors, supraoptic or paraventricular nuclei, or the supraopticohypophyseal trac B. Nephrogenic DI – decrease […]