Definition Donor heart, which is completely denervated, does not respond to manipulations of the parasympathetic nervous system (including reductions in parasympathetic outflow, ex. anticholinergics, anticholinesterases, or increases on PNS outflow, ex. phenylephrine), or neuronal SNS outflow (ex. cardioaccelerator fibers, although systemic epinephrine may still affect the heart). Furthermore, denervation impairs the response to changes in […]