Definition Anitfibrinolytics are frequently used in patients placed on CPB. The two available lysine analogs, ε-aminocaproic acid and tranexamic acid, bind to lysine binding sites on plasminogen and fibrinogen and thereby inhibit plasminogen activator and plasmin release. When administered before CPB, these agents clearly inhibit fibrinolysis, decrease mediastinal bleeding, and depending on the study, may […]