Definition Morphine and methadone are both opioids used in pediatric pain management. Morphine is more protein bound in adulthood than during the neonatal period (30% vs 20%). Morphine is metabolized to morphine 3-glucoronide and morphine 6-glucoronide. This occurs through sulfation and gluronidation. The enzymes guiding gluronidation are relatively immature in the neonate so preferentially more […]