Definition Amiloride is one of the four potassium sparing diuretics (others include spironolactone, eplerenone, and triamterene). Amiloride is most like triamterene in that they are both cations that directly decrease sodium channel activity in the principal cells in the cortical collecting tubule. Inhibition of sodium reabsorption at the cationic site prevents the secretion of potassium […]