Definition A K+ sparing diuretic with weak natriuretic and antihypertensive properties inhibits the epithelial Na channel (ENaC) in the late distal convoluted tubule and connecting tubules of the nephron (where 1-2% of total Na reabsorption occurs), effectively inhibiting Na reabsorption at this point. This creates an increased osmolarity in the nephron lumen compared to the […]