Definition Cerebral blood flow (CBF) is directly proportional to cerebral metabolic rate (CMR).  Cerebral perfusion pressure (CPP) is the difference between the mean arterial pressure (MAP) and intracranial pressure (ICP) or central venous pressure (CVP), whichever is greater.  Autoregulation maintains CBF relatively constant between a CPP of 50 and 150 mmHg in normotensive, healthy individuals. […]