Neostigmine, pyridostigmine, and edrophonium are primary excreted via both glomerular filtration and active tubular secretion. Neostigmine is water-soluble and roughly 50% of it undergoes renal excretion compared to 75% of pyridostigmine and edrophonium. Clearance of these drugs is significantly reduced in patients with ESRD and dosing adjustments may need to be made accordingly. When dosing […]