MAC Reduction Systemic local anesthetics reduce MAC of volatile anesthetics in rats by approximately 40% [DiFazio CA et al. Anesth Analg 55: 818, 1976], and in cats by as much as 59% [Pypendop BH et al. Anesth Analg 100: 97, 2005] FREE Full-text at Anesthesia & Analgesia. Wilson’s study of IV lidocaine (50-200 ucg/kg/min) […]