Ischemic Penumbra and Ischemic Thresholds Cortical potentials cease at 16-18 mL/100g/min, cell structure fails at 8-23 mL/100g/min. This also depends on duration – CBF of 18-23 mL/100g/min can be tolerated for two weeks, whereas 10-12 mL/100g/min can only be tolerated for 3 hours, and 8 mL/100g/min for one hour before neuronal death occurs [Acta Neurochir […]