Hypoxic pulmonary vasoconstriction was originally described in 1946, by Von Euler and Liljestrand – they were studying the effects of hypoxic gas mixtures, and found that PA pressures increased with 10.5% inspired O2 [Von Euler and Liljestrand. Acta Physiol Scand 12: 301, 1946]. Since then, HPV has been well-described in multiple mammalian models, including humans. […]