In this series, Thomas Dayspring, M.D., one of the world's most recognised experts in lipidology, shares his breadth of knowledge on heart disease prevention. Part 2 covers lipid transport, cholesterol removal from cells & HDL cholesterol.

VLDL, LDL & chylomicron residence time [02:03]

Apolipoprotein B (ApoB) & atherosclerosis [04:24]

Where are VLDL and chylomicron particles made ? [05:13]

Structure and function of triglycerides [05:40]

Triglyceride hydrolysis, genetics & lipoprotein lipase [06:40]

Phospholipids, phospholipid transfer protein & HDL synthesis from ApoA-I [09:50]

Function of ApoB & ApoA-I in the body [10:48]

What happens to VLDL & chylomicron remnants ? [14:14]

The LDL receptor-related protein (LRP) [15:50]

Apolipoprotein E (ApoE) [16:10]

Hepatic lipase, removal of ApoE in VLDL and a route to LDL [17:30]

HDL as cholesterol acceptors [17:53]

How does a HDL particle get rid of its cholesterol ? [20:58]

Difference between the LDL receptor & LDL receptor related protein [25:43]

Total, indirect & direct reverse cholesterol transport [26:10]

Why did evolution make LDL circulate for 3-5 days ? [27:00]

The big picture on lipid transportation [27:28]

How the Framingham Study created the misconception that raising HDL “good” cholesterol is all that matters ? [30:50]

Results from other clinical trials & HDL-C fallacies [32:30]

Interactive Quiz: https://www.surveymonkey.com/r/9PNWN8F

Give Tom a follow on Twitter: https://twitter.com/Drlipid

Other appearances from Tom:

Drive Podcast

https://www.youtube.com/watch?v=PllTHYgWpuw

Wellness: Fact vs. Fiction

https://podcasts.apple.com/us/podcast/a-masterclass-in-cholesterol-and-lipid-lowering/id1447250475?i=1000581954971

Nutrition Made Simple

lp(a):

https://www.youtube.com/watch?v=-WRRyG8il4g

Dietary cholesterol:

https://www.youtube.com/watch?v=GkWMDnTyxfo

Coronary Calcium Score (CAC):

https://www.youtube.com/watch?v=gxIeRUbHauw

Narrative glossary on lipids provided by Tom:

https://peterattiamd.com/glossary-lipids/

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