In this series, Thomas Dayspring, M.D., one of the world's most recognised experts in lipidology, shares his breadth of knowledge on heart disease prevention. Part 4 covers strategies to maximise longevity and reduce your risk of heart disease.
00:00 Intro
01:34 Target ApoB & Temporality
04:07 Ketogenic diet
08:12 Lipoprotein(a) & aortic stenosis
14:44 Oxidized phospholipids on apolipoprotein B-100 (OxPL-apoB)
16:51 Getting tested
18:25 Are statins “natural”?
20:55 Combination therapies
23:31 Triglycerides
26:18 Non-HDL cholesterol
27:06 Why is there no guideline for triglyceride therapy ?
27:51 Risk factors for Alzheimer's disease
34:45 Protocol to treat elevated ApoB
41:22 Tom's favourite books & textbooks
45:13 Meaning of life
50:31 Tom's ApoB
53:18 Tom’s intermittent fasting
57:06 Tom's daily routine
1:00:14 Outro
Here are the key metrics to shoot for in your lipid panel following the heart disease masterclass with Dr Thomas Dayspring.
Gold standard measure for heart disease risk
ApoB less than 80 mg/dl,
For people at high risk, less than 50 mg/dl
If the ApoB test is not available, there a couple of metrics related to ApoB that you can use:
LDL-C less than 70-100 mg/dl,
For people at high risk, less than 55 mg/dl
OR
non-HDL cholesterol less than 130 mg/dl
For people at high risk less than 70 mg/dl
Are you at risk of the lp(a) particle.
You only need to perform this once in your life. You are at risk if you reading is more than 30 mg/dL
Oxidized phospholipids on apolipoprotein B-100 (OxPL-apoB) could be a useful secondary test for those with high lp(a) to measure additional risk
You can also take phytosterol test (sitosterol, and campesterol) to check if you are hyper absorber of cholesterol. This is better than a genetic test
Triglycerides.
There is no guideline for triglyceride therapy, but a good value to shoot for could be:
less than 80-100 mg/dl
The human apolipoprotein E4 isoform (APOE4) is the strongest genetic risk factor for late-onset Alzheimer's disease (AD)
Give Tom a follow on Twitter: https://twitter.com/Drlipid
Other appearances from Tom:
Drive Podcast https://www.youtube.com/watch?v=PllTHYgWpuwWellness: Fact vs. Fiction https://podcasts.apple.com/us/podcast/a-masterclass-in-cholesterol-and-lipid-lowering/id1447250475?i=1000581954971Nutrition Made Simple lp(a): https://www.youtube.com/watch?v=-WRRyG8il4gDietary cholesterol: https://www.youtube.com/watch?v=GkWMDnTyxfoCoronary Calcium Score (CAC): https://www.youtube.com/watch?v=gxIeRUbHauw Narrative glossary on lipids provided by Tom: https://peterattiamd.com/glossary-lipids/
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