Hosts: Vincent Racaniello, Dickson Despommier, Alan Dove, Rich Condit, and Kathy Spindler

The Masters of the ScienTWIVic Universe discuss a novel poxvirus isolate from an immunosuppressed patient, H1N1 and the gain-of-function debate, and attenuation of dengue virus by recoding the genome.

Links for this episode * Paula Pitha-Rowe (Balt Sun) * Novel poxvirus (CID) * H1N1 and gain-of-function debate (mBio) * Recoding dengue virus genome (PNAS) * Attenuation by dinucleotide frequency change (PNAS) * Codon pair and dinucleotide bias not distinguished (PNAS) * Codon pair deoptimization artefact of CG/UA change (eLife) * Can engineering subdue viral vaccine reversion? (Virus Evol) * Attenuation by a thousand cuts (NEJM) * Image credit * Letters read on TWiV 351

Weekly Science Picks Alan - Genetic roulette Rich - The Huntington
Kathy - Simulated vomiting machine (video)
Dickson - Last Cassini Saturn flyby
Vincent - Decaying Still Life (YouTube)

Listener Pick of the Week Ken - Cave meterology (Times, Nature)

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