Michael Merchlinsky joins TWiV to discuss the development of two smallpox antiviral drugs and two smallpox vaccines and their uses during the monkeypox outbreak.

Hosts: Vincent Racaniello, Dickson Despommier, Rich Condit, and Kathy Spindler

Guest: Michael Merchlinsky

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Links for this episode * Michael on Anything but academic (TWiM 145) * Development of Tecoviromat (TPOXX) (Antiviral Res) * Use of Jynneos vaccine (MMWR) * Limitations of Tecoviromat (NEJM) * Poliovirus in NYC wastewater (NY Times) * Letters read on TWiV 927 * Timestamps by Jolene. Thanks!

Weekly Picks Dickson – Duke Ellington and his Orchestra. Signature song: Take The A Train; Signature album: Black, Brown, And Beige and Herding Cats: Harlem 1958
Kathy – How the US Postal Service reads terrible handwriting
Rich – JWST/chorizo gag
Vincent – Bat Conservation Trust

Listener Picks Bill – The End of Manual Transmission
J – How the Krebs cycle powers life and death – with Nick Lane

Intro music is by Ronald Jenkees

Send your virology questions and comments to twiv@microbe.tv