BUFFALO, NY — June 3, 2026 — A new #research paper was #published in Volume 18 of Aging-US on May 15, 2026, titled “Extracellular vesicles released by senescent myoblasts affect recipient cells via miRNA-target interactions.”The study was led by first author Michael Kamal from the Department of Kinesiology at McMaster University and corresponding author Gianni Parise from the same university.As people age, skeletal muscle gradually loses strength, size, and regenerative capacity. Scientists have increasingly linked these changes to cellular senescence—a state in which damaged cells permanently stop dividing but remain metabolically active. These senescent cells release a complex mixture of signaling molecules known as the senescence-associated secretory phenotype (SASP), which can influence neighboring cells and contribute to tissue dysfunction.In this study, the researchers investigated whether extracellular vesicles (EVs)—tiny membrane-bound particles released by cells—play a role in this process. Specifically, they examined EVs released by senescent muscle precursor cells, known as myoblasts, and analyzed the microRNAs (miRNAs) carried within these vesicles.The team found that senescent myoblasts released factors that impaired normal muscle cell development. When healthy muscle cells were exposed to signals from senescent cells, the resulting muscle fibers became significantly smaller and displayed increased expression of genes associated with cellular stress and senescence.Further analysis revealed that EVs released by senescent myoblasts carried a distinct set of miRNAs. The researchers identified 22 significantly altered miRNAs, including several previously linked to cellular senescence, such as miR-34a, miR-34b, miR-34c, and miR-22. The study also identified miR-301a-3p as a potentially novel senescence-associated miRNA.Full press release - https://aging-us.net/2026/06/03/senescent-muscle-cells-send-molecular-messages-that-may-contribute-to-age-related-muscle-decline/DOI - https://doi.org/10.18632/aging.206379Corresponding author - Gianni Parise - pariseg@mcmaster.ca Abstract video - https://www.youtube.com/watch?v=HKBbraYg8ewSign up for free Altmetric alerts about this article - https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.206379Subscribe for free publication alerts from Aging - https://www.aging-us.com/subscribe-to-toc-alertsKeywords - aging, cellular senescence, extracellular vesicles, myoblasts, miRNA, multi-omicsTo learn more about the journal, please visit https://www.Aging-US.com and connect with us on social media at:Bluesky - https://bsky.app/profile/aging-us.bsky.socialResearchGate - https://www.researchgate.net/journal/Aging-1945-4589X - https://twitter.com/AgingJrnlFacebook - https://www.facebook.com/AgingUS/Instagram - https://www.instagram.com/agingjrnl/LinkedIn - https://www.linkedin.com/company/aging/Reddit - https://www.reddit.com/user/AgingUS/Pinterest - https://www.pinterest.com/AgingUS/YouTube - https://www.youtube.com/@Aging-USSpotify - https://open.spotify.com/show/1X4HQQgegjReaf6Mozn6McMEDIA@IMPACTJOURNALS.COM