TAME (Targeting Aging with Metformin) aims to slow the aging process. It has been developed and approved by the National Institute of Aging and the FDA. The principal investigator, Nir Barzilai, is excited about changing the paradigm and getting big PHARMA to actually fund research for drugs (like metformin) for anti-aging.
Getting older is associated with heart disease, kidney disease, cancer, dementia, among other things. This is where metformin comes in. It helps slow down the major biochemical challenge of aging: glucose metabolism. Enzymes like insulin membrane receptors, mTOR, AMPK, and SIRT1 are implicated. And they are positively impacted by metformin.
Metformin is cheap (free at many pharmacies now). It's been used for decades. It's popular (the #1 oral drug for early type 2 diabetes). And it's safer than you think. Some medical sites (like Mayo) still incorrectly list lactic acidosis as a problem with metformin. But look up the multiple Cochrane analyses on this.
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