Zach and Brandon discuss the evidence for and against using probiotics as treatment for medical diseases and the mechanisms that may confer health benefits to individuals without disease.

Subjective:

0:45 - Brandon’s experience at the Metabolic Health Summit

10:19 - Introduction to probiotics

21:38 - Zach and Brandon’s probiotic protocol for themselves

24:25 - Introduction to the microbiome

Objective:

32:25 - Probiotics as treatment and prevention for type II diabetes and obesity 

45:08 - Treating digestive diseases with probiotics 

55:20 - Using probiotics to treat and prevent allergic rhinitis and eczema 

57:08 - Probiotics and depression

1:01:06 - Short-chain fatty acid (SCFA) effects on inflammation and innate immunity

1:18:00 - SCFAs and the gut-brain axis

1:24:34 - Insulin and satiety regulation through SCFAs

1:30:45 - Mitigating antibiotic side effects 

1:32:30 - What to look for: strains, dosage, viability, timing

1:40:10 - Safety concerns and side effects

Assessment/Plan:

1:43:50 - Conclusion, using probiotics for treatment and healthy individuals