2021 will be remembered as the year of many firsts in space. In the span of only a few months, we saw three billionaires, a pediatric cancer survivor, the winner of a Super Bowl sweepstakes, and the oldest person in history go to space. As the world watched in awe, a team at MITRE wondered what the increasing diversity of Spaceflight participants will mean for the future of Space Medicine—the science of how the human body is affected by traveling and living in a place that is fundamentally inhospitable to human life—i.e., outer space. With the democratization of space travel underway, how will we balance the health risks of space with our species’ existential need to explore what lies beyond our little blue planet?