With the discovery of CRISPR-Cas9 just under ten years ago, we gained the ability to precisely alter the human genome overnight. Now, with this hyper-precise “swiss army knife” of gene editing in hand, a MITRE biologist decides it’s time to assess the emerging techniques for delivering CRISPR into cells that are within the human body and finds a great deal of promise in the same drug delivery system that was used to deliver the mRNA COVID-19 vaccines. Meanwhile, a pediatric hospitalist discusses the pros and cons of using re-engineered viruses to deliver CRISPR and an immunogeneticist explains why we are on the cusp of curing a major disease with a CRISPR-based gene therapy. With so much potential for CRISPR to cure a broad range of genetic diseases, will researchers be able to overcome the safety issues that surround delivering CRISPR to the precise tissues in the human body that need editing?