In this episode, Lee, Nabil, and Andrew experiment with “vibe coding” bioinformatics tools using AI coding assistants. The goal: quickly build useful genomics utilities that run entirely in the browser via WebAssembly, without requiring command-line installs or servers. Nabil states: “Even if you don’t want to use this technology, you should pay attention - because everyone else will.”They discuss how existing bioinformatics programs can be compiled to WebAssembly and wrapped with simple browser interfaces so analyses run locally on a user’s machine. This keeps genomic data private while making tools easier to access.The prototype tools discussed in the episode are available here:https://genomicx.github.io/These examples show how browser-based bioinformatics might work for lightweight tasks such as genome comparisons and basic sequence analysis.Topics Covered Using AI tools to rapidly prototype bioinformatics software Compiling genomics programs to WebAssembly Running analyses locally in the browser Privacy advantages of keeping genomic data on the user’s computer* Practical limits of browser-based computationTry the tools and let us know what you think using the hashtag #genomicx