Since the beginning of the pandemic, skeptics have been saying that a SARS-CoV2 infection is like getting the flu... but is that true? Arutha shares his spatial data comparing Influenza-A lung tissue and SARS-CoV2 lung tissue. The results led to the development of a predictor of disease severity for COVID-19. We further discuss the workflow of moving from discovery to translation. Arutha also shares his thoughts on asking the right spatial questions and collaborating with pathologists to navigate and map tissues.