The Xapiens Podcast (XPC) Episode 11: Join Xapiens Co-Director Bobby Johnston in a discussion with Fei Chen. Fei is a core institute member at the Broad Institute of MIT and Harvard and an assistant professor in the Department of Stem Cell and Regenerative Biology at Harvard University. During the course of his doctoral research, Chen co-invented Expansion Microscopy. He completed his undergraduate degree at CalTech in EE before coming to MIT for his Ph.D. in biological engineering. Fei can sometimes be found playing basketball around MIT, which is how Bobby first met him, and eventually convinced him to talk on the podcast. Check out the Xapiens podcast on our website! https://xapiens-at-mit.captivate.fm/ Or listen to us on google podcast, spotify, amazon, apple podcasts or wherever you listen!
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RELEVANT LINKS: Fei Chen Lab: https://www.broadinstitute.org/bios/fei-chen DNA Dark Matter Detectors: https://arxiv.org/pdf/1206.6809.pdf Ticker Tape Paper: https://arxiv.org/ftp/arxiv/papers/1306/1306.5709.pdf Bionumbers: https://bionumbers.hms.harvard.edu/search.aspx?trm=ribosome+coli Inflation Calculator: https://www.usinflationcalculator.com/
OUTLINE: 0:00 - Expansion Microscopy in 120 seconds 2:12 - Introduction 3:12 - From EE to Biology 6:37 - Transition to Graduate School 9:53 - The Chen Lab 11:17 - What Do You Look for In Undergrads? 13:53 - Working as a Mentor 16:15 - Overview of Expansion Microscopy 26:02 - Does the Exact Expansion Factor Matter? 28:05 - ExMic + Electron Microscopy? 31:11 - Feeling of Discovery as a Grad Student 34:08 - Difficulties Along the Way 35:46 - From Grad School to Chen Lab 39:19 - How are Abundances of Genes Measured? 45:27 - The Cell as a State Machine 53:40 - Where is the ROM? 58:35 - Temporal Genomics and Dynamic Videos 1:07:19 - Overview of Slide Seq 1:19:31 - Are There Enough Tools in This Field? 1:24:00 - Sources of Inspiration 1:26:53 - OpenWetWare 1:33:00 - Advice to Young People