Artificial intelligence is changing the way drugs are being discovered. Find out how in this episode.
Episode Guest: Handol Kim, Co-Founder and CEO, VariationalAI.
Check out Ie-Knowledge Hub Video Case Studies on the International Entrepreneurship Knowledge Hub.
Questions or feedback on our episode? Get in touch with show host Thierry Harris: thierry.harris@cartouchemedia.com
Episode Research Question:
How can VariationalAI continue to work with pharma organizations to help develop better methods for validating their drug targets?
Write to us at solutions@ie-knowledgehub.ca and we'll post some of your answers on our website page.
Guest bio: Handol KimHandol is Co-Founder & CEO of Variational AI, an AI for drug discovery start-up based in Vancouver. Variational AI is applying its state-of-the-art generative AI to discover novel and drug-like small molecules that are efficacious, safe, and synthesizable in months versus years. Prior to co- founding Variational AI, Handol was General Manager of the Quadrant AI Business Unit of D-Wave Systems Inc, and brings over 20 years of executive management experience and leadership from venture-backed start-ups and publicly-listed technology companies in cloud, mobile/embedded, and telecommunications software in Silicon Valley, Canada and Asia Pacific. Variational AI is the third startup he has co-founded. Handol is Vice-Chair of the AI Network of British Columbia (AInBC) and a board director of the Digital Technology Supercluster and the United Way Lower Mainland.
Episode Links:
Variational AI
Handol Kim
CAMDEA Link to more on Variational AI
Drug Discovery
Medicinal chemistry
Small molecules definition
Small molecules drug production
Principles of Drug Discovery
Brute force approach to drug discovery
High throughput virtual screening
In-silico biology
Drug Targets
Short definition
Proteins as drug targets
Comprehensive Map of Drug targets
Further reading on drug targets
Drug Lead definition
Lipinski’s rule of five
Drug Assets definition
Drug Repurposing
Further reading on challenges of drug repurposing in COVID era
Biochemical Assays
SARS basics
Open source chemical repositories
Zinc
Pubchem
ChEMBL
AI terminology
Machine learning algorithms
Generative AI
Generative Vs discriminative AI models
Deep learning definition
Variational Encoders tutorial
Short Definition with mathematical examples
Original Alexnet paper
Paper outlining the significance of Alexnet work
Further reading on Alexnet
Krizhevsky papers
Image net
Hinton Lab university of Toronto
Krizhevsky’s work at university of Toronto and impact on Silicon Valley
Autonomist labs University of Toronto
Simon Fraser University Autonomous lab
Other links
Vancouver Prostate Center
Dr. Artem Cherkasov
Digital Supercluster
Bill Tam
Vancouver General Hospital
University of British Columbia
Photon etc.
Abcellera
ElementAI
Zymeworks
Admare BioInnovations
Atomwise
Recursion
Benevolent AI
Deep Genomics
Cyclica
Insilico
InVivo (now Valence)
NVIDIA
Biogen
Thierry Harris
Ie-Knowledge Hub Sponsorship Case
Photon etc Case Study
Thierry Harris
Market Hunt is produced by Cartouche Media in collaboration with Seratone Studios in Montreal and Popup Podcasting in Ottawa.
Market Hunt is part of the International Entrepreneurship Knowledge Hub network. Funding for this program comes from the Social Sciences and Humanities Resource Council of Canada.
Executive Producers: Hamid Etemad, McGill University Desautels Faculty of Management and Hamed Motaghi, Université du Québec en Outaouais.
Associate Producer, Jose Orlando Montes, Université du Québec à Montréal.
Technical Producers Simon Petraki, Seratone Studio and Lisa Querido, Pop up Podcasting.
Show consultant, JP Davidson. Artwork by Melissa Gendron. Voiceover: Katie Harrington.
You can check out the ie-Knowledge Hub Case studies at ie-knowledgehub.ca.