Glenn McConell chats with Professor David Wasserman from Vanderbilt University in Nashville, Tennessee, USA. David is recognised as an absolute authority on glucose homeostasis. His research focuses on how the system acts to protect sugar levels during exercise and disease.  This talk is wide ranging with a focus on the liver. We discuss the large range of roles of the liver, how it maintains blood glucose levels at rest and in particular during exercise. The role of circulating hormones in the regulation of liver glucose output during exercise is a focus. Professor Wasserman has been at the forefront of this aspect of hormonal research for over 30 years. We then discuss insulin resistance and the liver and how exercise can increase insulin sensitivity (reduce insulin resistance) in various organs, including the liver. In addition, we touch on organ cross talk during exercise.  David's father, Karlman Wasserman was a legend in exercise physiology and well known for his anaerobic threshold concept.  David proudly discusses how he was also a very well regarded and internationally renowned pulmonary physician who saved many lives, including once saving a woman's life who was choking in a restaurant, using his swiss army knife and a straw!  Twitter: @Inside_exercise @MouseCentral @GlennMcConell1