In her Science Insider story “U.S. scientists brace for greater scrutiny of risky research” (3 February, p. 422), J. Kaiser explains that recently issued recommendations (1) from the National Science Advisory Board for Biosecurity (NSABB) would require government oversight for all pathogen research. Although we strongly support the NSABB recommendations, we recognize that the disjointed federal oversight of biosafety and insufficient support could stymie their implementation. To operationalize effective biosecurity oversight systems, the US government must provide regulators and local institutional staff with the appropriate tools and resources.