Most conservative Bible scholars believe verses 20-22 have been completely fulfilled in history. The sticking points of disagreement occur with verse 23 and following. In my opinion, verses 23-25 could represent a near-far view. The near fulfillment sees Antiochus IV as the historical persecutor as in vv 9-14 -MacArthur-. Antiochus as king in 164 BC was -in the latter period of their rule.- Rome conquered Greece in 146 BC and Antiochus died -broken without human agency- from insanity and disease of the bowels.