Dr. Brendan McCarthy

Jump Off the Mood Swing: A Sane Woman's Guide to Her Crazy Hormones

Is weight gain really about willpower… or is something deeper going on?

In this episode, Dr. Brendan McCarthy, Chief Medical Officer at Protea Medical Center, breaks down the real biology behind stress, cravings, and weight gain—and why blaming yourself (or cortisol) is missing the point.

You’ll learn:

Why chronic stress rewires your metabolism
How stress drives cravings for ultra-processed foods
The truth about cortisol and fat storage
Why “just have more discipline” is bad medicine
How ultra-processed foods hijack your hunger and reward systems
The key to rebuilding control and agency

This isn’t about motivation—it’s about understanding your biology so you can finally work with your body instead of against it.

If you’ve ever felt stuck, frustrated, or blamed for your weight… this episode is for you.

Mechanism-Anchored References

Glucocorticoids, stress, and eating

Kuckuck S, van der Valk ES, Scheurink AJW, et al. Glucocorticoids, stress and eating: the mediating role of appetite-regulating hormones. Obesity Reviews. 2023.

Supports the claim that stress biology and glucocorticoid signaling can alter appetite regulation and eating behavior.

Stress-level glucocorticoids can increase hunger

Bini J, et al. Stress-level glucocorticoids increase fasting hunger and alter cerebral blood flow in neural regions that regulate food intake. 2022.

Supports the claim that stress-level glucocorticoid exposure can increase hunger and affect food-intake regulation.

Stress-obesity link / HPA-axis context

Lengton R, et al. Glucocorticoids and HPA axis regulation in the stress-obesity link. 2024.

Supports the broader claim that chronic stress and glucocorticoid biology are relevant to obesity risk and metabolic dysregulation.

Sleep loss changes appetite and metabolism

Van Cauter E, et al. Metabolic consequences of sleep and sleep loss. 2008.

Supports the claim that inadequate sleep alters appetite regulation and harms carbohydrate metabolism.

Sleep deprivation impairs glucose handling and raises appetite pressure

Knutson KL. The metabolic consequences of sleep deprivation. 2007.

Supports the claim that sleep loss can worsen glucose metabolism, appetite drive, and obesity risk.

Circadian disruption and metabolic dysfunction

Depner CM, et al. Metabolic consequences of sleep and circadian disorders. 2014.

Supports the claim that circadian disruption and sleep deficiency contribute to metabolic dysregulation and weight gain risk.

Ultra-processed food and reward-system activation

Calcaterra V, et al. Ultra-Processed Food, Reward System and Childhood Obesity. 2023.

Supports the claim that ultra-processed foods interact with reward pathways in ways that can drive intake beyond simple calorie math.

Ultra-processed food and metabolic dysfunction

Vitale M, et al. Ultra-Processed Foods and Human Health: A Systematic Review and Meta-Analysis. 2023.

Supports the claim that higher UPF consumption is associated with obesity and metabolic disease risk.

Stress and poorer diet quality / emotional eating

Shatwan IM, et al. Association between perceived stress, emotional eating, and diet quality. 2024.

Supports the claim that higher perceived stress is associated with worse dietary patterns and emotional eating.

Compassion-based framing and adherence

Sirois FM, et al. Self-Compassion and Adherence in Five Medical Samples. 2018.

Supports the closing point that shame is a weak intervention model and that compassion-linked framing may better support adherence and change.

Dr. Brendan McCarthy is the founder and Chief Medical Officer of Protea Medical Center in Arizona. With over two decades of experience, he’s helped thousands of patients navigate hormonal imbalances using bioidentical HRT, nutrition, and root-cause medicine. He’s also taught and mentored other physicians on integrative approaches to hormone therapy, weight loss, fertility, and more. If you’re ready to take your health seriously, this podcast is a great place to start.

👇 Tap Subscribe to learn more about what’s actually happening in your body, and what to do about it.

📘 Read Dr. McCarthy’s Book: Jump Off the Mood Swing – A Sane Woman’s Guide to Her Crazy Hormones https://www.amazon.com/Jump-Off-Mood-Swing-Hormones/dp/0999649604