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Those in the hot-and-heavy dating scene should know that post-exposure prophylaxis with the antibiotic doxycycline, called, Doxy-PEP, cuts the STD incidence rates by 70-80%. Infectious disease investigators in Boston and San Francisco studied data from 11,551 participants mean age 40 and 95% male with a high risk for contracting sexually transmitted disease.
The Doxy-PEP cut the risk of a chlamydia infection by 79% and the risk of syphilis by 80%, but the risk of gonorrhea by only 12%. The Doxy-PEP failed to better protect against gonorrhea due to causative bacterial resistance to the antibiotic.
While Doxy-PEP is currently highly effective, that could rapidly change. Antibiotic resistance to the prevalent bacteria that cause these diseases could increase at any time.
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2828994