Dr Luciana Hannibal, Research Group Leader / Head of Translational Metabolomics at the Centre for Integrative Biological Signalling Studies in Freiburg, and Dr Julien Park, a Physician-scientist at the Children's University Hospital Münster, are Rodrigo and Silvia's latest guests, providing a thorough overview of disorders of Redox Metabolism. Authors opinions are their own and do not represent their institutions.Papers discussed include:Targeted Metabolic Profiling of Methionine Cycle Metabolites and Redox Thiol Pools in Mammalian Plasma, Cells and UrineBehringer et alTreatment with 2-phospho-L-ascorbic acid mitigates biochemical phenotypes of heme oxygenase 1 deficiencyBerendes et alGuidelines for measuring reactive oxygen species and oxidative damage in cells and in vivoMurphy et alThe motor system is exceptionally vulnerable to absence of the ubiquitously expressed superoxide dismutase-1Park et alClinical and molecular analysis of a novel variant in heme oxygenase-1 deficiency: Unraveling its role in inflammation, heme metabolism, and pulmonary phenotypeBerendes et alRedox signaling in inherited diseases of metabolism,Current Opinion in PhysiologyJacobsen and HannbalReal-time detection of enzymatically formed hydrogen sulfide by pathogenic variants of cystathionine beta-synthase using hemoglobin I of Lucina pectinata as a biosensor.Myszkowska et al