How does the brain change itself, and can those changes be passed on to the next generation? ‘Yes’ and ‘yes’ according to Dr. Bryan Kolb, a neuroscientist at the University of Lethbridge, author of a classic neuropsychology textbook and a recipient of Canada’s highest civilian honor. Listen in to learn about brain plasticity as well as epigenetics, the science of how genes flip on and off and can be inherited in their new state.

TRANSCRIPT:

Intro: 0:01

Inventors and their inventions. Welcome to Radio Cade the podcast from the Cade Museum for Creativity and Invention in Gainesville, Florida. The museum is named after James Robert Cade, who invented Gatorade in 1965. My name is Richard Miles. We'll introduce you to inventors and the things that motivate them, we'll learn about their personal stories, how their inventions work and how their ideas get from the laboratory to the marketplace.

Richard Miles: 0:38

Brain plasticity, and epigenetics. What do those terms mean? And why do they matter? I'm your host Richard Miles, and I'm very pleased to welcome a very distinguished guest, Dr. Bryan Kolb neuroscientist at the University of Lethbridge in Canada, the author of numerous books and articles on neuropsychology and the recipient of the order of Canada, Canada's highest, Civilian honor. Welcome to Radio Cade Bryan.

Bryan Kolb: 0:59

Thank you.

Richard Miles: 1:01

Bryan. I read somewhere that your groundbreaking textbook Fundamentals of Neuropsychology, is the most stolen book in England. What is up with that?

Bryan Kolb: 1:08

Well, apparently it's true. It's stolen form libraries that obviously doesn't happen in Canada or the U.S. People buy the book. We had a heck of a time getting it published in the late 1970s, because nobody believed there was such a field and it turns out there is and the book did very well.

Richard Miles: 1:24

For an author obviously an author would like to get paid on the sales, but to have your book stolen probably better than your book being dropped off at used bookstores. But let's talk about that. The book itself was very important because it was pathbreaking breaking . It's published in , I think in 1980. And you talked about brain plasticity, not just that, but that was one of the fundamental things. And basically your definition, I believe is the ability of the brain to reorganize its structure, function and connections in response to experiences. So why don't you sort of walk our listeners through, what does that mean? How can we think about brain plasticity in a useful way?

Bryan Kolb: 2:01

If you imagine being born into the world, the brain has no idea what world its going to be, could be in Alaska? It could be at the equator. You could be in Africa. And so the brain biologically needs to be able to change itself, to adapt to the environment that it's in. That's sort of the background as to why evolution would have done this. It's not just true of us. It's true in worms. So all animals have this capacity to change their brain response to the environment that they find themselves in. And of course, if your listeners would learn anything from this discussion today, we have to change their brains. Somehow distorted material, the brain has to change. It's just not magic.

Richard Miles: 2:39

So If I understand this correctly and we're not stuck with the brain were born with right? Basically from the minute we're born, the brain is constantl