Obesity and Cancer- Your Fault or Your Genetics

intro conversation

Does genetics impact you getting obese.

Maybe;

Genetics minor role

Your choices and circumstances can increase or decrease your genetic risk

This means we can somewhat control it

A few hundred years ago we werent eating and very active to survive

hence why we have fat to store

Society allows easy access- and we eat excess

Good news is that you have the control this

Anyone can lose weight

Calories in vs out

Decreased metabolism, diabetes, complicate

But unhealthy life style caused it

Changing to a healthy one early enough reverses it and many others.

Genetics and obesity FTO

Cant deny environments part on making us obese, but how much does genetics matter?

“Runs in the family” - habits, not genetics

Italian pasta sedentary family- kids become?

Our genes didn’t suddenly change 100 years ago.(obesity)

however 100-ish genetic markers linked to obesity.

all of them together account for less than 3% difference in BMI between people

. The “fat gene” (called FTO, “FaT mass and Obesity associated’’) most linked

less than 1 percent difference between people- 0.34 percent.

Do you have FTO?

Who cares- results in a few hundred extra calories per year

In other words, no; those genes don’t make you look fat.

FTO gene has appears weaker among physically active,

may be abolished in those eating healthier diets.

FTO only appears to affect certian high sat/tran fats and sugar

Thos active and healthy eating, no increased weight gain risk even with fto from both parents

FTO gene status does not appear to affect your ability to lose weight.

We were designed for food to be addicting

Obesity does usually become lack of willpower

Eat right, workout right, live well)drink smoke)

Our environment makes us use self control for food

Id love to eat a bunch of junk too, some of it is delicious!- moderate

We are designed to eat everything, and move to survive- not required anymore

its why we crave sugar and fat- fast and high cal

Since food wasnt always available, those that could eat the most survived the longest.,

We no longer need to be active to be alive, so we have to do it voluntarily a lot- exercise

Cancer and genetics

Cancer= mutations, then uncontrolled growth

External- tobacco, alcohol, standing in radioactive sludge, south park microwave etc

Internal- “random cellular changes

Inherited mutations-

Different; in the dna of every cell

Genetics affect cancer, but so does environment

Inherited genetic mutations plays role in 5 to 10 percent of all cancers

Slightly more with hormonal cancers in generl

Colon CA- has been increasing 1% to 3% annually- not solely genetic

Our environment will activate those susceptible to cancer

Cancer growers- like kidney stone growers

.Genetic testing for cancers-

can, but may not want to, depends.

Suggested if

several close relatives have had it,

if youve had it or another cancer before,

Just want to be proactive

Have a physical trait suggesting CA- Café-au-lait spots

Neurofibromatosis-

Genetic, changes nerve growth, causes nerve tumors

10% to 25% have café-au-lait spots; NF

is suspected when a person has 6 or more

Cancer and Enviroment-

“Everything causes cancer now”

Cleaners, tobacco, alcohol, standing in radioactive goo, cooking with foil

Cancer percentage has increased

Especially younger adults, 20-50yrs

heavily correlated with youth obesity

Excess body fat increases

Colorectal, uterine, kidney, pancreatic and more

constantly from inflammation

Visceral fat releases estrogens

higher estrogen levels increase cell production, could result in tumor growth,”

Fat cells release proinflammatides

Ending thoughts?

Healthy lifestyle = diet AND exercise people.

healthy lifestyle can help prevent and treat diseases more than genetics

Not excuses for why youre unhealthy, find reasons and ways to change it

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