The Centres for Disease Control and Prevention, CDC, has said Americans should avoid cruises regardless of their vaccination status. This is due to concerns over Omicron spread. The CDC stated that the virus can quickly spread in the confined spaces of a ship, and that the likelihood of infections is high.
Even fully vaccinated passengers who have received a booster shot can spread the virus while onboard. The recommendation also includes testing between one and three days prior to the voyage, and three to five days after, irrespective of vaccination status. Equally important, is to self-isolate for a week for those unvaccinated.